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The gastrointestinal epithelium represents an important interface between the host and the external environment, serving both as a surface for absorption as a defence against ingested pathogens

The uncontrolled generation of GSSG during oxidative stress can contribute to mitochondrial dysfunction by glutathionylation of target proteins, as described below

10.1186/s12931-022-02123-5 Respir Res

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Tumor emergence is sensed by self-specific CD44hi memory Tregs that create a dominant tolerogenic environment for tumors in mice